The Molecular Heterogeneity of Nonspecific Cross-reacting Antigen Synthesized by Tumor Cells and Granulocytes
نویسندگان
چکیده
منابع مشابه
Molecular cloning of nonspecific cross-reacting antigens in human granulocytes.
To clarify the molecular structures of nonspecific cross-reacting antigens (NCAs), a family of glycoproteins antigenically related to carcinoembryonic antigen (CEA), in human granulocytes, we have screened a cDNA library of human leukocytes using a cDNA probe for the N-terminal domain (domain-N) of NCA-50, an NCA species in tumor cells. In 95 positive clones randomly selected, we identified six...
متن کاملRole of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes.
Nonspecific cross-reacting antigen (NCA) is the name of a family of highly glycosylated bacterial-binding receptors found on human granulocytes and other tissues. These glycoproteins are members of the immunoglobulin supergene family and are related structurally to carcinoembryonic antigen. In this study, we demonstrate that ligation of granulocyte NCA results in the activation of the cells, as...
متن کاملImmunohistological localization of carcinoembryonic antigen and nonspecific cross-reacting antigen in gastrointestinal normal and tumoral tissues.
The localization of the Carcinoembryonic antigen (CEA) of gastrointestinal tumors and of the nonspecific crossreacting antigen (NCA) was studied by immunocytological techniques in various cancerous and noncancerous diges tive tissues. NCA was found having the same centroglandular local ization than CHA, in cancerous and noncancerous glands of colonie and gastric mucosae. The only difference was...
متن کاملEarly detection of colorectal cancer metastasis and relapse by recognizing nonspecific cross-reacting antigen 2 in commercial carcinoembryonic antigen assays.
Carcinoembryonic antigen (CEA), one of the first known tumor markers, is still the most useful clinical marker to aid in the diagnosis and monitoring of colorectal cancer. Many commercial assays are available for measuring CEA, but their practical use is complicated by the molecular heterogeneity of CEA. CEA is a heavily glycosylated protein of the immunoglobulin gene superfamily and has severa...
متن کاملNonspecific cross-reacting antigen 50/90 is elevated in patients with breast, lung, and colon cancer.
A total of 22 genes have been identified in the carcinoembryonic antigen (CEA) gene family. The protein products of this family are highly homologous and include CEA, biliary glycoprotein, nonspecific cross-reacting antigen 50/90 (NCA 50/90), NCA 95, and pregnancy-specific beta-glycoprotein. We used a monoclonal antibody with high affinity to develop a specific enzyme-linked immunosorbent assay...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1988
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1988.tb00014.x